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A recent study suggests that the key to weight loss might be influenced by a combination of 14 so-called "skinny genes." Researchers found that people with these genetic markers were able to lose significantly more weight through exercise compared to those without the same genes.

Participants with the highest number of these genetic markers shed up to 11 pounds after eight weeks of running, compared to just over 4 pounds for those without the genetic advantage.

“This study highlighted some important genes associated with weight loss, but it’s crucial to remember that these genes need to be activated through exercise and lifestyle changes,” said lead researcher Henry Chung, a lecturer at the University of Essex School of Sport, Rehabilitation and Exercise Sciences in the U.K. “Without intervention, the genes won’t show their true potential, so it doesn’t matter what genes you have unless you engage in a healthy lifestyle.”

For the study, 38 participants aged 20 to 40 were divided into two groups. Half were asked to run for 20 to 30 minutes, three times a week while keeping their usual diet and habits unchanged. The other half served as a control group.

The findings highlighted that one particular gene, PPARCG1A, played a crucial role in weight loss. This gene is involved in energy metabolism and was more prevalent among those who lost the most weight during the study. The other identified "skinny genes" are associated with diet, fat storage, metabolism, and even psychological factors.

The study showed that about 62 per cent of weight loss success could be attributed to genetics, while the remaining 37 per cent was tied to exercise and lifestyle factors. Researchers concluded that understanding a person’s genetic profile could potentially lead to personalized exercise and diet plans for better health outcomes in the future.

Chung emphasized that while genetics play a significant role, everyone can benefit from exercise, regardless of their genetic makeup. “Exercise has numerous benefits beyond weight loss, such as improving mental health and cardiovascular fitness. I’d advise everyone to keep exercising, even if the scales aren’t showing immediate changes,” he said.

The study was published in the journal Research Quarterly for Exercise and Sport, and it opens the door for more research into how genetics and exercise interact to influence weight loss and overall health.

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